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Adenocarcinoma - Adenocarcinoma of kidney (PH 1720) (pp. 114-116)
(Be able to identify the slide showing kidney cancer; identify normal glomeruli and tubules; and differentiate between normal and diseased regions.)

Note that tubular cells have undergone extensive proliferation and have lost their characteristic appearance. They look more like undifferentiated cells and there is extensive stroma filled with red blood cells between the cancer cells. See Fig. 8-9. This situation is very different from that of the benign adenoma of the colon. Compare the tumor with the normal kidney structure (tubules and glomeruli) by moving the slide back and forth. Note that the tumor is displacing and invading into the normal kidney tissue. There is no sharp boundary between normal and malignant tissue. Return the slide to the area of the tumor.   


                                         Normal kidney - cortex region(40X2.0)
                                       
                                        Approximately twelve glomeruli, each surrounded by tubules 

Adenocarcinoma of kidney (40X2.0)                                         Adenocarcinoma of kidney (40X2.0)
    
Normal kidney tubules at right, neoplasia at left                   Neoplasia at right, hemorrhaging neoplasia at center and left

* Why is this called an adenocarcinoma?

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8Copyright 2001 - Augustine G. DiGiovanna - All rights reserved.

This material may not be reproduced or distributed in any form or by any means, or stored in any data base or retrieval system without prior written permission is obtained from Augustine G. DiGiovanna, Ph.D.,  Professor of Biology, Salisbury University, Salisbury, MD  21801.